Selected Publications

Selected Publications

The complete bibliography of Prof. Dr. Leif Erik Sander is available at PubMed

  1. Vanshylla K, Tober-Lau P, Gruell H, Münn F, Eggeling R, Pfeifer N, Le NH, Landgraf I, Kurth F*, Sander LE*, Klein F*. Durability of omicron-neutralising serum activity after mRNA booster immunisation in older adults. Lancet Infect Dis. 2022;22(4):445–6. Available from: https://doi.org/10.1016/S1473-3099(22)00135-9
  2. Wang Z, Muecksch F, Muenn F, Cho A, Zong S, Raspe R, Ramos V, Johnson B, Ben Tanfous T, DaSilva J, Bednarski E, Guzman-Cardozo C, Turroja M, Millard KG, Tober-Lau P, Hillus D, Yao K-H, Shimeliovich I, Dizon J, Kaczynska A, Jankovic M, Gazumyan A, Oliveira TY, Caskey M, Bieniasz PD, Hatziioannou T, Kurth F*, Sander LE*, Nussenzweig MC*, Gaebler C*. Humoral immunity to SARS-CoV-2 elicited by combination COVID-19 vaccination regimens. J Exp Med. 2022;219(10). Available from: https://doi.org/10.1084/jem.20220826
  3. Gruell H, Vanshylla K, Tober-Lau P, Hillus D, Schommers P, Lehmann C, Kurth F*, Sander LE*, Klein F*. mRNA booster immunization elicits potent neutralizing serum activity against the SARS-CoV-2 Omicron variant. Nat Med. . Nature Medicine. 2022. Available from: https://doi.org/10.1038/s41591-021-01676-0
  4. Wendisch D*, Dietrich O*, Mari T*, Stillfried S v.*, Ibarra IL, Mittermaier M, Mache C, Chua RL, Knoll R, Timm S, Brumhard S, Krammer T, Zauber H, Hiller AL, Pascual-Reguant A, Mothes R, Bülow RD, Schulze J, Leipold AM, Djudjaj S, Erhard F, Geffers R, Pott F, Kazmierski J, Radke J, Pergantis P, Baßler K, Conrad C, Aschenbrenner AC, Sawitzki B, Landthaler M, Wyler E, Horst D, Hippenstiel S, Hocke A, Heppner FL, Uhrig A, Garcia C, Machleidt F, Herold S, Elezkurtaj S, Thibeault C, Witzenrath M, Cochain C, Suttorp N, Drosten C, Goffinet C, Kurth F, Schultze JL, Radbruch H, Ochs M, Eils R, Müller-Redetzky H, Hauser AE, Luecken MD, Theis FJ, Conrad C, Wolff T*, Boor P*, Selbach M*, Saliba A-E*, Sander LE*. SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis. Cell. 2021. Available from: https://doi.org/10.1016/j.cell.2021.11.033
  5. Tober-Lau P*, Schwarz T*, Vanshylla K*, Hillus D*, Gruell H, Suttorp N, Landgraf I, Kappert K, Seybold J, Drosten C, Klein F, Kurth F*, Sander LE*#, Corman VM*. Long-term immunogenicity of BNT162b2 vaccination in older people and younger health-care workers. The Lancet Respiratory Medicine. 2021;9(11):e104-e105. Available from: https://doi.org/10.1016/S2213-2600(21)00456-2
  6. Hillus D*, Schwarz T*, Tober-Lau P, Vanshylla K, Hastor H, Thibeault C, Jentzsch S, Helbig ET, Lippert LJ, Tscheak P, Schmidt ML, Riege J, Solarek A, Kalle C v., Dang-Heine C, Gruell H, Kopankiewicz P, Suttorp N, Drosten C, Bias H, Seybold J, Klein F, Kurth F*, Corman VM*, Sander LE*. Safety, reactogenicity, and immunogenicity of homologous and heterologous prime-boost immunisation with ChAdOx1 nCoV-19 and BNT162b2: a prospective cohort study. The Lancet Respiratory Medicine. 2021. Available from: https://doi.org/10.1016/S2213-2600(21)00357-X
  7. Loyal L*, Braun J*, Henze L*, Kruse B*, Dingeldey M*, Reimer U*, Kern F*, Schwarz T*, Mangold M, Unger C, Dörfler F, Kadler S, Rosowski J, Gürcan K, Uyar-Aydin Z, Frentsch M, Kurth F, Schnatbaum K, Eckey M, Hippenstiel S, Hocke A, Müller MA, Sawitzki B, Miltenyi S, Paul F, Mall MA, Wenschuh H, Voigt S, Drosten C, Lauster R, Lachman N, Sander LE*, Corman VM*, Röhmel J*, Meyer-Arndt L*, Thiel A*, Giesecke-Thiel C*. Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination. Science. 2021. Available from: https://doi.org/10.1126/science.abh1823
  8. Kreye J*, Reincke SM*, Kornau H-C, Sánchez-Sendin E, Corman VM, Liu H, Yuan M, Wu NC, Zhu X, Lee C-CD, Trimpert J, Höltje M, Dietert K, Stöffler L, Wardenburg N v., van Hoof S, Homeyer MA, Hoffmann J, Abdelgawad A, Gruber AD, Bertzbach LD, Vladimirova D, Li LY, Barthel PC, Skriner K, Hocke AC, Hippenstiel S, Witzenrath M, Suttorp N, Kurth F, Franke C, Endres M, Schmitz D, Jeworowski LM, Richter A, Schmidt ML, Schwarz T, Müller MA, Drosten C, Wendisch D, Sander LE, Osterrieder N, Wilson IA, Prüss H. A Therapeutic Non-self-reactive SARS-CoV-2 Antibody Protects from Lung Pathology in a COVID-19 Hamster Model. Cell. 2020;183(4):1058-1069.e19. Available from: http://dx.doi.org/10.1016/j.cell.2020.09.049
  9. Schulte-Schrepping J*, Reusch N*, Paclik D*, Baßler K*, Schlickeiser S*, Zhang B*, Krämer B*, Krammer T*, Brumhard S*, Bonaguro L*, De Domenico E*, Wendisch D*, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu C-J, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Müller-Redetzky H, Heim K-M, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jürgens L, Stegemann M, Glösenkamp CR, Volk H-D, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, Kalle C v., Kurth F, Händler K, Schultze JL*#, Aschenbrenner AC*#, Li Y*#, Nattermann J*#, Sawitzki B*#, Saliba A-E*#, Sander LE*#. Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell. 2020;182(6):1419-1440.e23. Available from: http://dx.doi.org/10.1016/j.cell.2020.08.001
  10. Braun J*, Loyal L*, Frentsch M*, Wendisch D, Georg P, Kurth F, Hippenstiel S, Dingeldey M, Kruse B, Fauchere F, Baysal E, Mangold M, Henze L, Lauster R, Mall MA, Beyer K, Röhmel J, Voigt S, Schmitz J, Miltenyi S, Demuth I, Müller MA, Hocke A, Witzenrath M, Suttorp N, Kern F, Reimer U, Wenschuh H, Drosten C, Corman VM, Giesecke-Thiel C*, Sander LE*, Thiel A*. SARS-CoV-2-reactive T cells in healthy donors and patients with COVID-19. Nature. 2020;587(7833):270–4. Available from: http://dx.doi.org/10.1038/s41586-020-2598-9
  11. Chua RL*, Lukassen S*, Trump S*, Hennig BP*, Wendisch D*, Pott F, Debnath O, Thürmann L, Kurth F, Völker MT, Kazmierski J, Timmermann B, Twardziok S, Schneider S, Machleidt F, Müller-Redetzky H, Maier M, Krannich A, Schmidt S, Balzer F, Liebig J, Loske J, Suttorp N, Eils J, Ishaque N, Liebert UG, Kalle C v., Hocke A, Witzenrath M, Goffinet C, Drosten C, Laudi S, Lehmann I*, Conrad C*, Sander LE*, Eils R*. COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis. Nat Biotechnol. 2020;38(8):970–9. Available from: http://dx.doi.org/10.1038/s41587-020-0602-4
  12. Herold S, Sander LE. Toward a universal flu vaccine. Science. 2020;367(6480):852–3. Available from: http://dx.doi.org/10.1126/science.aba2754
  13. Georg P, Sander LE. Innate sensors that regulate vaccine responses. Curr Opin Immunol. 2019;5931–41. Available from: http://dx.doi.org/10.1016/j.coi.2019.02.006
  14. Ugolini M*, Gerhard J*, Burkert S*, Jensen KJ, Georg P, Ebner F, Volkers SM, Thada S, Dietert K, Bauer L, Schäfer A, Helbig ET, Opitz B, Kurth F, Sur S, Dittrich N, Gaddam S, Conrad ML, Benn CS, Blohm U, Gruber AD, Hutloff A, Hartmann S, Boekschoten MV, Müller M, Jungersen G, Schumann RR, Suttorp N, Sander LE. Recognition of microbial viability via TLR8 drives TFH cell differentiation and vaccine responses. Nat Immunol. 2018;19(4):386–96. Available from: http://dx.doi.org/10.1038/s41590-018-0068-4
  15. Garaude J, Acín-Pérez R, Martínez-Cano S, Enamorado M, Ugolini M, Nistal-Villán E, Hervás-Stubbs S, Pelegrín P, Sander LE, Enríquez JA, Sancho D. Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense. Nat Immunol. 2016;17(9):1037–45. Available from: http://dx.doi.org/10.1038/ni.3509
  16. Blander JM, Sander LE. Beyond pattern recognition: five immune checkpoints for scaling the microbial threat. Nat Rev Immunol. 2012;12(3):215–25. Available from: http://dx.doi.org/10.1038/nri3167
  17. Sander LE, Davis MJ, Boekschoten MV, Amsen D, Dascher CC, Ryffel B, Swanson JA, Müller M, Blander JM. Detection of prokaryotic mRNA signifies microbial viability and promotes immunity. Nature. 2011;474(7351):385–9. Available from: http://dx.doi.org/10.1038/nature10072